• All iPSC derived neurons demonstrated expression

  2018-11-08

  

  All iPSC-derived neurons demonstrated expression of functional neurotransmitter receptors, responding to glutamate/glycine, GABA and to a lower extend to acetylcholine. Interestingly, the neuronal cultures also developed synchronized spontaneous calcium oscillations, which were likely to reflect met

• br Resource table Resource details The

  2018-11-08

  

  Resource table. Resource details The study was approved by the Singhealth ethics committee (protocol number SHSIBC-2014-031), and written informed consent was obtained from the patient. 2ml of peripheral blood sample was obtained from a male 64-year-old Parkinson\'s disease patient carrying a he

• The numbers of GFAP NSCs did not return

  2018-11-08

  

  The numbers of GFAP+ NSCs did not return to control levels at even the longest survival times examined (approximately 1 month after AraC and GCV treatment). One possible explanation for this is that we simply did not wait long enough to observe the complete return to control values. Alternatively, t

• Importantly this recent paper Gonzalez Cordero

  2018-11-08

  

  Importantly, this recent paper (Gonzalez-Cordero et al., 2013) together with our work confirms the capacity of pluripotent stem cells to provide a renewable source of cells to produce photoreceptors in vitro and highlights the great interest of using the 3D culture system developed by Sasai’s group.

• br Experimental Procedures Detailed Experimental Procedures

  2018-11-08

  

  Experimental Procedures Detailed Experimental Procedures are provided in the Supplemental Experimental Procedures. Author Contributions Acknowledgments Introduction For an adequate quantitative production of each blood cell lineage in homeostasis and in stress conditions, the fate of he

• filipin Following fundamental analysis of pharmacological

  2018-11-08

  

  Following fundamental analysis of pharmacological and electrophysiological features of suspension-derived CMs, we have demonstrated direct applicability of bioreactor-produced EBs for tissue engineering. While BCT generation from undissociated, contracting spheres was recently shown, this required g

• br Experimental Procedures br Author

  2018-11-08

  

  Experimental Procedures Author Contributions Acknowledgments Introduction The vital processes of blood coagulation, clot formation, and hemostasis rely upon a sufficient supply of platelets within a person’s bloodstream. Transfusion remains the most effective way to increase a patient’s

• Recently using the cynomolgus macaque PGCs were first

  2018-11-08

  

  Recently using the cynomolgus macaque, PGCs were first identified in the amnion of the peri-implantation embryo at day 11 (Sasaki et al., 2016). The amnion develops coincident with the generation of the amniotic cavity and formation of the bilaminar embryo (Fig. 1, arrow points to amnion cells in th

• br Experimental Procedures br Acknowledgments br Introductio

  2018-11-08

  

  Experimental Procedures Acknowledgments Introduction Dopamine (DA) cell replacement for Parkinson’s disease (PD), using transplantation of human fetal ventral mesencephalic tissue to the striata of PD patients, has provided proof of principle that DA-neuron-rich grafts can survive long term

• Our limited understanding of huSC biology can

  2018-11-08

  

  Our limited understanding of huSC biology can be attributed in part to the difficulty of obtaining tissue samples and of isolating a pure population of huSCs (Boldrin et al., 2010). By comparison, techniques for the prospective isolation of mouse SCs have identified a well-defined myogenic SC popula

• In summary we demonstrated that OCT is critical for mesendod

  2018-11-08

  

  In summary, we demonstrated that OCT4 is critical for mesendoderm differentiation by showing its involvement in eviction of the PRC2 complex and loss of the H3K27me3 mark from mesendodermal genes. The effect on SOX17 is most revealing as it demonstrates pre-patterning of this gene prior to gene expr

• br Experimental Procedures br Author Contributions br Acknow

  2018-11-08

  

  Experimental Procedures Author Contributions Acknowledgments The authors thank Chyuan-Sheng Lin from the Transgenic Mouse Facility at the Herbert Irving Comprehensive Cancer Center at Columbia University for development of the Zfyve27-CreERT2 mice; Theresa Swayne from the Confocal and Speci

• Further studies were carried out on

  2018-11-08

  

  Further studies were carried out on miR-146a-5p, which is thought to be a mediator of inflammation, and a regulator of IL-6 and IL-8 and the expression of the immune receptors TLR2 and 4 (Taganov et al., 2006). TLRs are present on a range of non-immune cells, and a number (predominantly TLR2 and TLR

• The phenotype and fate of a given cell

  2018-11-08

  

  The phenotype and fate of a given cell relies on the precise control of gene expression by complex transcriptional and epigenetic networks. Such regulation of gene expression is essential for proper differentiation, cellular function, development, and homeostasis (Feng et al., 2010; Reik, 2007). His

• Noticeably the redistribution of protein from

  2018-11-07

  

  Noticeably, the redistribution of protein from the cytoplasm to the nucleus was observed in many regulatory molecules, such as nuclear factor κB (Haddad, 2009) and AKT (Xuan et al., 2006). We thus speculated that the increased nuclear MIF in hypoxic tumors may interact with the transcription factors

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