• Because the rate of intestinal perforation is

  2018-10-29

  

  Because the rate of intestinal perforation is high (> 30%) with chemotherapy, some authors suggest that surgical resection could prevent this complication and improve patient outcomes. Nevertheless, some authors argue that PCL originating from intestinal lymphoid tissue should be treated as a system

• br Acknowledgement br Introduction Murraya paniculata L

  2018-10-29

  

  Acknowledgement Introduction Murraya paniculata (L.) belongs to the Rutaceae family. This plant is native to areas in Southeast Asia [1], such as Southern China, Vietnam and Malay Peninsula. In China, the ornamental plant M. paniculata is widely cultivated on the sides of the road for decorati

• br Introduction Dietary fibers demonstrated to have imperati

  2018-10-29

  

  Introduction Dietary fibers demonstrated to have imperative role in improvement and management of human health, especially gastrointestinal system. However, type and source of dietary fiber greatly influence their functional properties. At present, the primary sources employed in food industries

• A repeatable and scalable process of hES cell derivation and

  2018-10-29

  

  A repeatable and scalable process of hES cell derivation and scale-up would require a xenofree, clinical grade feeder cell line. Choo et al. generated a hES feeder cell line using HPV E6/E7 immortalization but this line has not become widely used (Choo et al., 2006). More recently Unger et al. used

• The generation of neural cells from patients with

  2018-10-29

  

  The generation of neural mth1 inhibitor from patients with MS is an important first step towards a new avenue of MS research. Disease modeling using iPS-generated cells has already improved understanding of a number of rare conditions including spinal muscular atrophy (Ebert et al., 2009), Timothy

• Another hypothesis for the process of mineralization concent

  2018-10-29

  

  Another hypothesis for the process of mineralization concentrates on the appearance of matrix vesicles (MV). According to this hypothesis cells emit MVs into the extracellular space (Barckhaus et al., 1981; Bonucci, 1981) via exocytosis. It is suggested that a selective ion pump regulates ion deposi

• Recently we and others demonstrated that

  2018-10-29

  

  Recently, we and others demonstrated that cells with astroglial characteristics and radial processes are still present in specific regions of the adult brain. These cells are termed radial glia-like cells (RGLCs) and they are present in the SVZ and in the SGL (Alvarez-Buylla et al., 2002; Gubert et

• br Results br Discussion Despite the widespread clinical use

  2018-10-29

  

  Results Discussion Despite the widespread clinical use of hMSCs, there are fundamental gaps in our knowledge of basic MSC biology. In contrast to HSCs, the molecular mechanisms that maintain MSCs in their undifferentiated state or determine their differentiation pathways are still poorly under

• br Experimental Procedures br Author Contributions br

  2018-10-29

  

  Experimental Procedures Author Contributions Acknowledgments Introduction The cornea is a multilayered, transparent, and avascular structure forming the anterior part of the eye. Its outermost layer, the corneal epithelium, is exposed to the external environment and thereby needs to be r

• To identify the label retaining cells within the myocardium

  2018-10-26

  

  To identify the label-retaining BI6727 within the myocardium, BrdU was administrated and the intensity of the BrdU signal was examined after a prolonged chasing period (Urbanek et al., 2006). As expected, the number of bright BrdU-CSCs in the atria decreased rapidly after chasing while the number of

• The finding that MHC and myogenin

  2018-10-26

  

  The finding that MHC and myogenin expression does not change upon ectopic Msx1 expression but decreases drastically upon Msx2 expression is another piece of evidence for the selective role of MSX2 in dedifferentiation. The previous two studies on MSX1 induction in myotubes did not characterize MHC l

• Our study showed that neurite length

  2018-10-26

  

  Our study showed that neurite length and the ratio of apoptotic GSK-J1 sodium salt in FALS- and FUSH517D/H517D iPSC-derived neurons were the same as in control motor neurons. With several stresses especially in glutamate treatment, however, FALS- and FUSH517D/H517D HB9-positive motor neurons exhibi

• Both NHEJ and HDR have been

  2018-10-26

  

  Both NHEJ and HDR have been used in hPSCs for gene editing (Byrne et al., 2015; Chen et al., 2014b; Ding et al., 2013a; Ding et al., 2013b; Genga et al., 2015; Hockemeyer et al., 2011; Hou et al., 2013; Kleinstiver et al., 2016; Slaymaker et al., 2016). For targeted gene knockout in hPSCs, NHEJ usua

• It is important to note that although

  2018-10-26

  

  It is important to note that although RB1 inactivation is unique to retinoblastoma initiation, it is functionally inactivated in most human neoplasms (Weinberg, 1995); therefore, utilizing RB1-mutant mps1 as a drug screen platform could benefit other malignancies as well. In conclusion, we have ge

• Using the measured approach curves we determined the force a

  2018-10-26

  

  Using the measured approach curves, we determined the force acting on the probe from the sample surface as the product of the cantilever spring constant k by the piezoscanner movement value dZ (this quantity is plotted on the abscissa in Fig. 2b). Next, we constructed the F(δ) dependences to find Yo

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