• To meet this current need our

  2018-10-22

  

  To meet this current need, our goal was to develop a tool that would make automated cell segmentation feasible and efficient in analyzing data from higher organisms, as has been applied to less complex data from lower organisms, such as in bacteria (Locke and Elowitz, 2009). The objective was to ass

• Inner pillar cells express Fgfr which may contribute to thei

  2018-10-22

  

  Inner pillar cells express Fgfr3, which may contribute to their capacity for regeneration (Jacques et al., 2007). Supporting cells in the chicken basilar papilla express Fgfr3, which is transiently downregulated during hair cell regeneration (Bermingham-McDonogh et al., 2001). Fgfr3−/− mice lack in

• A potent methodology was recently developed to generate a

  2018-10-22

  

  A potent methodology was recently developed to generate a highly enriched population of floor-plate-derived midbrain lineage ESC-mDA and iPSC-mDA neurons sufficient to treat the large PD patient population (Kriks et al., 2011). Cellular Dynamics International made a critical translational advancemen

• br Materials and methods br Results br Discussion

  2018-10-22

  

  Materials and methods Results Discussion Posttranscriptional regulation mechanisms are now considered to play a key role in the control of gene expression. Regulation occurs mainly through the modulation of mRNA half life or the formation of a translational initiation complex, allowing the

• Although the expression of bisect type N glycans during

  2018-10-20

  

  Although the chk1 inhibitor of bisect-type N-glycans during neuronal differentiation was significantly up-regulated, this did not occur during glial differentiation. This result indicates that increased bisect-type N-glycan expression is specific to neuronal differentiation. Therefore, bisecting ty

• Several studies have reported pivotal

  2018-10-20

  

  Several studies have reported pivotal roles for some miRNAs in hBMSC-lineage commitment and fate determination that are mediated by their ability to modulate differentiation-regulating factors. For instance, miR-210, miR-206, miR-133, miR-2861, and miR-138 have been implicated in the regulation of o

• To investigate whether PD derived HSCs

  2018-10-20

  

  To investigate whether PD-derived HSCs exist in other mammals, we analyzed the resident cells in the peritoneal cavity of C57BL/6 mice without any prior treatment. We found that there was a higher ratio (0.51±0.04%) of Lin−/Sca1+/c-kit+ population in the mouse peritoneal cavity than in bone marrow (

• br Materials and methods br

  2018-10-20

  

  Materials and methods Acknowledgments We would like to thank Ida Jørring and Anita Pacht for their excellent technical assistance. This project was funded by the European Union 7th Framework Program (PIAPP-GA-2012-324451-STEMMAD) and Innovation Fund Denmark through BrainStem. Resource table

• br Resource table br Resource details Spastic paraplegia

  2018-10-20

  

  Resource table Resource details Spastic paraplegia gene type 5 (SPG5) is an autosomal recessive subtype of hereditary spastic paraplegia caused by mutations in CYP7B1, a gene encoding for the cytochrome P-450 oxysterol 7-α-hydroxylase, essential for the liver-specific alternative pathway in bi

• More recently work has been performed in

  2018-10-20

  

  More recently, work has been performed in the NHP species, Macaca fasicularis (the crab-eating macaque), in which autologously transplanted iPS-derived dopamine neurons were able to survive and restore motor deficits for up to 2years (Hallett et al., 2015). However, the degree to which studies inves

• The pluripotency of MPSII line was confirmed by alkaline

  2018-10-20

  

  The pluripotency of MPSII-4.1 line was confirmed by alkaline phosphatase staining (ALP) and by immunocytochemistry staining (ICC) for endogenous NANOG and -CADHERIN (B) after silencing of the exogenous hOKSM construct. The spontaneous differentiation potential of the iPSC line towards the three ge

• Telomere elongation is one of

  2018-10-20

  

  Telomere elongation is one of the hallmarks of the reprogramming process, and we previously showed that this is a two-step process: it starts during reprogramming and then continues while iPSCs have obtained full pluripotent status (Marion et al., 2009). In Sirt1−/− cells, the telomere elongation af

• The meniscus is best described as

  2018-10-20

  

  The meniscus is best described as a fibrocartilage (Benjamin and Evans, 1990) comprising an outer, “red vascularized” part and an inner “white, unvascularized” part harboring round fibrochondrocytes (Hellio Le Graverand et al., 2001). Additionally, the outer surface of the meniscus is enclosed by a

• Our findings showing an increase of growth factors expressio

  2018-10-20

  

  Our findings showing an increase of growth factors expression in miR133-CPCs upon stress conditioning and the amelioration of cardiac functions after miR133-CPCs transplantation post-AMI are in agreement with a recent publication that demonstrates that previous supplementation (“priming”) of SCA1+/C

• We exploited C MYC to activate the endogenous c

  2018-10-20

  

  We exploited C-MYC to activate the endogenous c-Myc gene and enhance gene expression in neurosensory cell types. By doing so, we derived a self-renewing immortalized multipotent otic progenitor (iMOP) line from SOX2-expressing neurosensory precursors of the inner ear. We show that the endogenous C-M

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