• Protein microarrays represent just one of a variety of

  2024-09-02

  

  Protein microarrays represent just one of a variety of experimental approaches that can be used to generate datasets of relevance to pathway mapping. Other approaches include protein (+)-Apogossypol profiling techniques, such as antibody arrays [29], tissue arrays [30] and 2-dimensional gel electro

• Cy5.5 NHS ester br Experimental section br Acknowledgment S

  2024-09-02

  

  Experimental section Acknowledgment S.B.T. is grateful to the Deutsche Forschungsgemeinschaft (DFG), the Wilhelm Sander-Stiftung and Interdisciplinary Center for Molecular Materials (ICMM) for generous research support. M.M. greatly acknowledges the experimental support and the scientific cont

• br Acknowledgements We thank the National Natural

  2024-09-02

  

  Acknowledgements We thank the National Natural Science Foundation of China (41576156), Shandong Province Science and Technology Development Plan (2015GSF121045), Yantai Science and Technology Development Plan (2015ZH078), and the Public Science and Technology Research Funds Projects of Ocean (No.

• br AR signals and chemosensitivity in urothelial cancer A

  2024-09-02

  

  AR signals and chemosensitivity in urothelial cancer A significant amount of patients with urothelial cancer fail to respond to cisplatin-based systemic chemotherapy, although it remains the mainstay of successful management of advanced disease. However, underlying mechanisms for chemoresistance

• In another study Yerra and Kumar used streptozotocin to

  2024-09-02

  

  In another study, Yerra and Kumar (2016) used streptozotocin to induce diabetic neuropathy in rats. Mechanical/thermal hyperalgesia, motor/sensory nerve conduction velocities (MNCV and SNCV) and sciatic nerve blood flow (NBF) were evaluated. In vitro studies of Neuro2a (N2A) cell culture were perfor

• Table reports the results for the categorical

  2024-09-02

  

  Table 3 reports the results for the categorical coding of diagnosis. The categorical coding is less hypothesis driven than the continuous coding because it allows for nonlinear interactions that are driven by only two groups (CN → MCI stable, CN → MCI progressor, and CN → AD). That said, this analys

• br We approached the definition of AD

  2024-09-02

  

  We approached the definition of AD with the distinction between a syndrome and a disease in mind. Some will argue that a specific syndrome, that is, a multidomain amnestic dementia (after other potential etiologies have been excluded), should define AD in living people. Our position, however, is t

• Previous studies to investigate the functions of

  2024-09-02

  

  Previous studies to investigate the functions of AHR in Treg 3146 have employed a loss-of-function approach, using AHR complete-null mice, or a gain-of-function approach by ligand administration. However, these approaches may confound the interpretation of the results. For example, the broad expres

• Protein blast analysis of the sequence

  2024-08-31

  

  Protein blast analysis of the sequence of globin-B with those of other cytochalasin d suggests that the globin-B domain in the HemAC-Lm displays only 6% identity and 34% similarity with that of cytoglobin/neuroglobin (Fig. 2). Furthermore, SWISS-MODEL protein modeling also predicts that the His311

• br Conclusion br Conflicts of interest

  2024-08-31

  

  Conclusion Conflicts of interest Compliance with ethical standards Introduction Tuberculosis is one of the leading causes of morbidity and mortality, amongst infectious diseases. India is a high burden country for Tuberculosis. Caused by Mycobacterium tuberculosis, it DCPIB mg can prese

• br Acknowledgements br Introduction Resistant hypertension R

  2024-08-31

  

  Acknowledgements Introduction Resistant hypertension (RH), is defined as blood pressure (BP) > 140/90 mm Hg despite three full doses antihypertensive drugs including a diuretic. Controlled hypertensive patients taking four lactone receptor or more of antihypertensives are also considered resis

• Introduction The lysosomal storage disorder Gaucher disease

  2024-08-31

  

  Introduction The lysosomal storage disorder Gaucher disease (Mendelian Inheritance in Man, OMIM #230800) results from the recessively inherited deficiency of lysosomal glucocerebrosidase (GCase, EC 3.2.1.45), caused by mutations in the gene GBA1 (MIM# 606463) located on chromosome 1q21. The enzymat

• br Acknowledgements br Introduction Thus

  2024-08-31

  

  Acknowledgements Introduction Thus, damage to the dna synthesis may produce severe consequences (National Research Council, 1992). Indeed, though the nervous system has several compensatory and adaptive mechanisms, it is vulnerable to toxic insult, due to its inability to regenerate after leth

• Functional enhancers are often composed of binding motifs of

  2024-08-31

  

  Functional enhancers are often composed of binding motifs of multiple key transcription factors to confer spatial and temporal regulation of genes in a certain context. In the uterus, the difference between the number of genes that have associated PGR occupancy and that of progesterone responsive ge

• At the outset of targeting the two Gln

  2024-08-31

  

  At the outset of targeting the two Gln756 side-chain rotamers, it was unclear which rotational isomer would lead to more potent ASK1 inhibitors. While such a preference might have been anticipated, the cohort of ASK1 inhibitors in Table 3 did not provide any guidance regarding which of the Gln756 am

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