• br Substoichiometric substrate modification E

  2021-02-27

  

  Substoichiometric substrate modification E3 ligases catalyze the rapid transfer of the SUMOD from the E2 enzyme to the substrate. By definition, enzymes are recycled in the reaction, allowing multiple rounds of substrate modification by a single enzyme. Thus, enzymes function at substoichiometric

• E protein expressed in a

  2021-02-27

  

  E1 protein expressed in a plasmid encoding codon-optimized canine oral papillomavirus (COPV) led to therapeutic immunization of COPV-infected Beagle dogs [25], [26], which was better than that achieved with plasmids encoding E2 or E7 COPV. Moreover, E1 and E2 from cottontail rabbit papillomavirus (C

• In conclusion by investigating the cysteine

  2021-02-26

  

  In conclusion, by investigating the cysteine protease transcriptome in soybean nodules, we found a number of cysteine proteases belonging to the C1 and C13 families strongly up-regulated following drought exposure such as C1 cysteine protease Glyma.14G085800 and C13 cysteine proteases Glyma.17G23070

• br Materials and methods br Results The

  2021-02-26

  

  Materials and methods Results The i.v. administration of urocortin 2 reduced the mean arterial blood pressure in a dose-dependent manner (Fig. 1). The ED50 for the urocortin 2 cumulative dose–response effect on mean arterial blood pressure was 0.014±0.004 mg kg−1. Urocortin 2 administration ha

• It is of interest to point

  2021-02-26

  

  It is of interest to point out that curcumin in this study reduced body weight gain; the underlying mechanism may be due to a decrease in general dna-pkcs of fat, which was associated with a significantly reduced NPC1L1 expression in small intestine. Labonte et al revealed that NPC1L1 deficiency or

• Similarly to other investigations the

  2021-02-26

  

  Similarly to other investigations, the present study found that ZEA in high concentrations decreases viability of both normal (Liu et al., 2018, Zheng et al., 2018a, Zheng et al., 2018b) and cancer Edrophonium chloride (Khosrokhavar et al., 2009, Kowalska et al., 2017). The toxic effect of ZEA obser

• MAPKs are a family of phosphorylating enzymes

  2021-02-26

  

  MAPKs are a family of phosphorylating enzymes that orchestrate various cellular response in proliferation, apoptosis, inflammation, stress response, and energy metabolism [11]. There are at least four major members including extracellular signal-regulated kinase 1 and 2 (ERK1/2), p38 mitogen-activat

• Although information regarding the influence of PGE on

  2021-02-26

  

  Although information regarding the influence of PGE2 on cardiac fibroblast cell growth is sparse, the effect of PGE2 on other cell types has been studied extensively, particularly in cancer and cancer cell lines where COX-2 is over-expressed. Constitutive high levels of COX-2 expression have been no

• br Materials and methods br

  2021-02-26

  

  Materials and methods Results Discussion Inflammatory signalling and in particular the arachidonic NCT-502 cascade have been suggested as targets for disease modification, optimization of the therapeutic response, and even restoration of pharmacosensitivity (Potschka, 2010). Recently, we d

• Kif15-IN-1 Whichever interactions are formed between the DS

  2021-02-26

  

  Whichever interactions are formed between the DS domains and the collagen ligand, they are expected to lead to structural changes within the DDR dimer that are propagated across the cell membrane to result in DDR autophosphorylation (Noordeen et al., 2006). Tight coupling of the extracellular confor

• From these and other studies it is

  2021-02-26

  

  From these and other studies, it is clear that acriflavine is an interesting Cy3 carboxylic acid (non-sulfonated) with pleiotropic anticancer effects [21], [22], [43]. Its past systemic use in the clinical setting as an antibiotic without any major toxicity reported encourages further development o

• br Mechanisms of acquired resistance to st and nd generation

  2021-02-26

  

  Mechanisms of acquired resistance to 1st and 2nd generation EGFR inhibitors After treatment with first or second generation EGFR TKIs, virtually all patients after approximately 12 months develop acquired resistance (AR). Different mechanisms of AR to EGFR TKIs have been reported to date and may

• EBI and its ligand s EBI

  2021-02-26

  

  EBI2 and its ligand(s) EBI2 was found in a screen of upregulated genes in human B cells upon infection with EBV [1]. EBI2 is a G-protein (Gαi type) coupled receptor [2] but as long as 18 years after its discovery the nature of its ligand remained undisclosed. With the help of transfected cell lines

• All components of the UPP were predicted to be

  2021-02-26

  

  All components of the UPP were predicted to be susceptible to oxidative stress due to the cysteine residues in their active sites [36]. Curcusone D inhibits DUBs but has no significant effect on the action of E1, E2s, E3s, or the proteasome, which indicates that the targets of the ROS induced by cur

• br Introduction The ubiquitination status of a target protei

  2021-02-26

  

  Introduction The ubiquitination status of a target protein is achieved via a delicate balance between two opposing forces: ubiquitin E3 ligases and DUBs. It has been postulated that the majority of proteins in a cell are regulated and modified by ubiquitin at some point (Hershko and Ciechanover,

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