• It is interesting that of the

  2021-02-27

  

  It is interesting that of the control groups, female TG controls only had significantly higher MB-COMT protein than non-TG male controls (Supplemental Table 9, P = 0.005), while these two groups have almost equal expression of S-COMT protein (8.54- vs. 8.34-fold) and their COMT enzyme activity is al

• br Acknowledgements This work was supported in part

  2021-02-27

  

  Acknowledgements This work was supported in part by JSPS KAKENHI Grant Number 26292031. Introduction The Cys-loop receptors constitute an important superfamily of ligand-gated ion Pirfenidone (LGICs) and mediate synaptic transmission in both invertebrate and vertebrate nervous systems (Jones

• br Materials and methods br Results br Discussion

  2021-02-27

  

  Materials and methods Results Discussion Cells in the human body, especially in the cardiovascular and musculoskeletal systems, undergo a variety of mechanical stimuli. In order to ensure human movement, the strength of stretching muscles acts on cartilage and bone, moving joints through te

• Only a few studies have examined the effect

  2021-02-27

  

  Only a few studies have examined the effect of prostanoids on cardiac fibroblasts. Therefore, this study examines the effect of PGE2 on cardiac fibroblast proliferation and tests the hypothesis that PGE2 causes cardiac fibroblast proliferation via alterations of ixazomib regulatory molecules and th

• br Materials and methods br Results br Discussion The nitric

  2021-02-27

  

  Materials and methods Results Discussion The nitric oxide generating enzymes of the NOS family comprise three isoforms: nNOS, iNOS and eNOS [31]. Expression of eNOS is mainly found in endothelial 97 9 mg where it physically promotes vasodilation [32]. Conversely, evidence also indicates tha

• There are conflicting studies on ET axis and its relationshi

  2021-02-27

  

  There are conflicting studies on ET axis and its relationship with clinicopathologic parameters in various cancers. Endothelin axis expression in the tissue and in blood has been associated with advanced cancer characteristics in colorectal, breast, and prostate cancer, while showing no linkage to c

• br Substoichiometric substrate modification E

  2021-02-27

  

  Substoichiometric substrate modification E3 ligases catalyze the rapid transfer of the SUMOD from the E2 enzyme to the substrate. By definition, enzymes are recycled in the reaction, allowing multiple rounds of substrate modification by a single enzyme. Thus, enzymes function at substoichiometric

• E protein expressed in a

  2021-02-27

  

  E1 protein expressed in a plasmid encoding codon-optimized canine oral papillomavirus (COPV) led to therapeutic immunization of COPV-infected Beagle dogs [25], [26], which was better than that achieved with plasmids encoding E2 or E7 COPV. Moreover, E1 and E2 from cottontail rabbit papillomavirus (C

• In conclusion by investigating the cysteine

  2021-02-26

  

  In conclusion, by investigating the cysteine protease transcriptome in soybean nodules, we found a number of cysteine proteases belonging to the C1 and C13 families strongly up-regulated following drought exposure such as C1 cysteine protease Glyma.14G085800 and C13 cysteine proteases Glyma.17G23070

• br Materials and methods br Results The

  2021-02-26

  

  Materials and methods Results The i.v. administration of urocortin 2 reduced the mean arterial blood pressure in a dose-dependent manner (Fig. 1). The ED50 for the urocortin 2 cumulative dose–response effect on mean arterial blood pressure was 0.014±0.004 mg kg−1. Urocortin 2 administration ha

• It is of interest to point

  2021-02-26

  

  It is of interest to point out that curcumin in this study reduced body weight gain; the underlying mechanism may be due to a decrease in general dna-pkcs of fat, which was associated with a significantly reduced NPC1L1 expression in small intestine. Labonte et al revealed that NPC1L1 deficiency or

• Similarly to other investigations the

  2021-02-26

  

  Similarly to other investigations, the present study found that ZEA in high concentrations decreases viability of both normal (Liu et al., 2018, Zheng et al., 2018a, Zheng et al., 2018b) and cancer Edrophonium chloride (Khosrokhavar et al., 2009, Kowalska et al., 2017). The toxic effect of ZEA obser

• MAPKs are a family of phosphorylating enzymes

  2021-02-26

  

  MAPKs are a family of phosphorylating enzymes that orchestrate various cellular response in proliferation, apoptosis, inflammation, stress response, and energy metabolism [11]. There are at least four major members including extracellular signal-regulated kinase 1 and 2 (ERK1/2), p38 mitogen-activat

• Although information regarding the influence of PGE on

  2021-02-26

  

  Although information regarding the influence of PGE2 on cardiac fibroblast cell growth is sparse, the effect of PGE2 on other cell types has been studied extensively, particularly in cancer and cancer cell lines where COX-2 is over-expressed. Constitutive high levels of COX-2 expression have been no

• br Materials and methods br

  2021-02-26

  

  Materials and methods Results Discussion Inflammatory signalling and in particular the arachidonic NCT-502 cascade have been suggested as targets for disease modification, optimization of the therapeutic response, and even restoration of pharmacosensitivity (Potschka, 2010). Recently, we d

16383 records 721/1093 page Previous Next First page 上5页 721722723724725 下5页 Last page