• Significantly less is known about regulation of phytocystati

  2020-12-25

  

  Significantly less is known about regulation of phytocystatin gene expression. A genomic clone corresponding to the barley cystatin Icy gene has been characterized (Gaddour et al., 2001) and the function of its promoter region has been analysed by Martínez et al. (2005b). Bioinformatic analysis of t

• A variety of fused membered ring chemotypes have

  2020-12-25

  

  A variety of fused 6–5-membered ring chemotypes have arisen such as 7-azaindole acetic acids, benzimidazolyl acetic acids, spiro-indolinone acetic acids, and indolizine acetic acids, however, to the best of our knowledge, fused 5,5-membered ring systems have not been reported. Prostaglandin D (PG

• It has been reported that NMDA receptor hypofunction upregul

  2020-12-25

  

  It has been reported that NMDA receptor hypofunction upregulates the expression of immediate early genes in several PHA 543613 hydrochloride receptor regions [39], [40]. Consistent with this finding, we demonstrated that MK-801 increased the number of c-Fos-positive cells in the PVN and PC/RS (Fig.

• In this study we observed alterations in mRNA levels

  2020-12-25

  

  In this study, we observed alterations in mRNA levels of CRF receptors in the PFCx and Hip during the development of sensitization. In particular, in the Hip both CRF receptors showed significantly increased GSA 10 when the sensitization condition was established. Similarly, CRF2 receptor increase

• fty720 br Advantages of modified proteins over

  2020-12-24

  

  Advantages of modified proteins over unmodified ones In contrast to small-molecule drugs, proteins are readily amenable to site-specific alterations through genetic engineering. In principle, therefore, it is possible to build in features that allow them to remain active for longer in the body an

• Stable carbon and nitrogen isotope ratios in bone collagen a

  2020-12-24

  

  Stable carbon and nitrogen isotope ratios in bone collagen and carbon isotope ratios in bone apatite data were obtained by the means of the techniques described in supplementary data (SD1). For collagen, standard indicators have been used to assess its preservation, such as collagen yield, carbon an

• br Materials and methods br

  2020-12-24

  

  Materials and methods Results Recently, a quantitative proteomic analysis of C2C12 mouse myoblasts cell line totally deprived of protein kinase CK2 catalytic subunits (CK2α/CK2α′(−/−)), suggested that the cellular expression of HSP27, a chaperone with multiple functions related to proteostasis

• Interestingly from our consensus SBVC protocol only few comp

  2020-12-24

  

  Interestingly, from our consensus SBVC protocol only few compounds (less than 150) have been scored with a full ‘ consensus’. That means that these compounds appear in the top 5% of the database when ranked by every scoring function independently. After visual inspection, we have realized that two a

• It should be noted that not

  2020-12-24

  

  It should be noted that not only glyphosate but E2 at the same concentration range (10−11-10−7 M) also showed similar effects on the expression of the 3 bromopyruvate regulating proteins. Furthermore, we could not see a significant difference among this concentration range of glyphosate and E2 on o

• UVRAG is a mammalian ortholog

  2020-12-24

  

  UVRAG is a mammalian ortholog of yeast Vps38 and a promoter of autophagy [51,60,61]. It forms distinct complexes with BECN1 (mammalian ortholog of yeast Vps30/Atg6) and the class III phosphatidylinositol 3-kinase (whose catalytic subunit [PIK3C3] is the mammalian ortholog of yeast Vps34) and contrib

• While previously reported optimizations on compound focused

  2020-12-24

  

  While previously reported optimizations on fluvastatin receptor focused on the phenyl ring A () and substituents on isoxazole ring, other alternatives to replace isoxazole ring were never explored. Herein, we propose to replace the isoxazole with its bioisosteric substituted phenyl ring B () to ex

• The assembly and maturation of invadopodia can

  2020-12-24

  

  The assembly and maturation of invadopodia can be initiated by chemical stimuli such as the epidermal growth factor (EGF), as well as the mechanical signals from extracellular matrix (ECM). Upon binding, EGF activates the EGF receptor (EGFR), which further activates several intracellular signaling p

• The Acat gene was identified by functional complementation o

  2020-12-24

  

  The Acat1 gene was identified by functional complementation of a Chinese hamster ovary cell mutant lacking ACAT activity [12]. Unlike most other genes, human Acat1 is located in two different chromosomes, geldanamycin 1 and 7, with each site containing a distinct promoter: chromosome 1 contains exo

• To our knowledge this is the first report

  2020-12-24

  

  To our knowledge, this is the first report of an oncocytoma expressing alpha-enolase or causing autoimmune retinopathy and optic neuropathy. Although generally considered benign, oncocytomas have rarely been associated with paraneoplastic syndromes, including tumor-induced hypertension, erythrocytos

• Our study revealed elevated basal Akt phosphorylation in die

  2020-12-24

  

  Our study revealed elevated basal Akt phosphorylation in diet-induced obesity, the effect of which was reversed by ETAKO. Activation of Akt promotes cardiac hypertrophy via a number of cellular mechanisms including activation of its downstream targets such as mTOR and GSK3β [45, 46]. Short-term acti

16383 records 758/1093 page Previous Next First page 上5页 756757758759760 下5页 Last page