• That DGAT mediated hepatic steatosis did not lead

  2019-08-16

  

  That DGAT-mediated hepatic steatosis did not lead to insulin resistance was clearly demonstrated in Liv-DGAT2-low mice by their normal blood glucose and plasma insulin levels, normal glucose and insulin tolerance, normal insulin sensitivity by hyperinsulinemic-euglycemic clamp studies, and normal he

• This study demonstrates that GUL affects multiple pathways

  2019-08-16

  

  This study demonstrates that GUL-1 affects multiple pathways/processes. As GUL-1 is likely to function as an RNA-binding protein, it is conceivable that the mRNAs involved are bound to GUL-1 as part of the regulatory function of the protein. In fact, in S. cerevisiae Ssd1 was shown to bind multiple

• Introduction Excessive exposure to ultraviolet UV irradiatio

  2019-08-16

  

  Introduction Excessive exposure to ultraviolet (UV) irradiation from the sun injures human skin, which might lead to premature aging and skin pathologies [1], [2]. Chronic exposure to UV (especially ultraviolet-B, UVB) irradiation could profoundly affect the skin epidermis, interfering with the ker

• Introduction Maintenance of genome integrity

  2019-08-16

  

  Introduction Maintenance of genome integrity is essential for life, and faithful DNA replication and repair ensure this. One of the most important parameters for DNA maintenance is the regulation of optimal concentrations of the four 5′-deoxyribonucleoside-triphosphates (dNTPs) the precursors for

• On the other hand the

  2019-08-16

  

  On the other hand, the death domain is a conserved stretch of around 80AA which is commonly found in death receptor proteins, it play a major role in the interaction between other proteins. Also as a platform for the death-inducing signaling complex (DISC) formation (Chaigne-Delalande et al., 2008).

• The study reported here had the primary goal to compare

  2019-08-16

  

  The study reported here had the primary goal to compare the methylation of HPV late genes with methylation of the DAPK promoter, and with histological or cytological diagnoses among high-risk patients that were referred to a colposcopy clinic based on abnormal cervical cytology. Based on the literat

• Second when considering the Poisson point process the high

  2019-08-16

  

  Second, when considering the Poisson point process, the high-density or large-radius limit of the percolation probability tends to 1 exponentially fast and is governed by the isolation probability. In the random environment, the picture is more subtle since the regime of a large radius is no longer

• br Regulation of p via the ubiquitin proteasome pathway Stud

  2019-08-15

  

  Regulation of p53 via the ubiquitin-proteasome pathway Studies into regulation of p53 via PTM processes that involve phosphorylation, acetylation, ubiquitination, SUMOylation, neddylation, and methylation are being increasingly reported [23], [24]. Phosphorylation and acetylation of p53 stimulate

• The number of DBH alleles affects dopamine

  2019-08-15

  

  The number of DBH VEGFR Tyrosine Kinase Inhibitor II affects dopamine and norepinephrine levels in the prefrontal cortex of mice when they are treated with disulfiram (33). Disulfiram increased dopamine and decreased norepinephrine levels in their prefrontal cortex of mice with two normal alleles,

• Contrary to the profuse dopaminergic innervation of the thal

  2019-08-15

  

  Contrary to the profuse dopaminergic innervation of the thalamus found in human and non-human primates (Brown et al., 1979, Sanchez-Gonzalez et al., 2005), in rodents, the RTn is one the few thalamic nuclei that receives dopaminergic input (Anaya-Martinez et al., 2006, Garcia-Cabezas et al., 2007, G

• Tumor associated macrophages TAMs one of

  2019-08-15

  

  Tumor-associated macrophages (TAMs)—one of the limiting factors in anti-tumor immunity—are associated with the poor clinical outcome in most carcinomas, owing to their potential to promote angiogenesis and local invasion, increase the metastasis of tumor cells, and inhibit the anti-tumor immunity.11

• br Acknowledgments This study was supported by grants from

  2019-08-15

  

  Acknowledgments This study was supported by grants from the Spanish Ministry of Economy and CompetitivenessPI10/00387, PI12/01087, PI12/01703, IPT-2011-0817-010000, and RIC Red de Investigación Cardiovascular (RIC)RD12/0042/0055. RIC is an initiative of Instituto de Salud Carlos III (ISCIII), Spa

• br Materials and methods br Results br Discussion UPP

  2019-08-15

  

  Materials and methods Results Discussion UPP components including the proteasome, E1s, E2s, E3s and DUBs may become one the most important EW-7197 of therapeutic targets for the pharmaceutical industry in the near future and supersede those which are involved in the phosphorylation system

• Given the fact that most criticism

  2019-08-15

  

  Given the fact that most criticism on genetic association studies is the lack of replicability (Hirschhorn, Lohmueller, Byrne, & Hirschhorn, 2002), the aim of the present study is to investigate the influence of the DBH polymorphism rs1611115 (C-970T) on RD in two independent samples of healthy part

• Introduction Double strand break DSB

  2019-08-15

  

  Introduction Double strand break (DSB) is the most deleterious damage that threats DNA integrity. This frequent damage arises from environmental stress like UV, chemical agents or ionizing radiations (IRs). Although environmental stress does not lead directly to DSB, it produces 5-moUTP in damage,

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