• filipin Following fundamental analysis of pharmacological

  2018-11-08

  

  Following fundamental analysis of pharmacological and electrophysiological features of suspension-derived CMs, we have demonstrated direct applicability of bioreactor-produced EBs for tissue engineering. While BCT generation from undissociated, contracting spheres was recently shown, this required g

• br Experimental Procedures br Author

  2018-11-08

  

  Experimental Procedures Author Contributions Acknowledgments Introduction The vital processes of blood coagulation, clot formation, and hemostasis rely upon a sufficient supply of platelets within a person’s bloodstream. Transfusion remains the most effective way to increase a patient’s

• Recently using the cynomolgus macaque PGCs were first

  2018-11-08

  

  Recently using the cynomolgus macaque, PGCs were first identified in the amnion of the peri-implantation embryo at day 11 (Sasaki et al., 2016). The amnion develops coincident with the generation of the amniotic cavity and formation of the bilaminar embryo (Fig. 1, arrow points to amnion cells in th

• br Experimental Procedures br Acknowledgments br Introductio

  2018-11-08

  

  Experimental Procedures Acknowledgments Introduction Dopamine (DA) cell replacement for Parkinson’s disease (PD), using transplantation of human fetal ventral mesencephalic tissue to the striata of PD patients, has provided proof of principle that DA-neuron-rich grafts can survive long term

• Our limited understanding of huSC biology can

  2018-11-08

  

  Our limited understanding of huSC biology can be attributed in part to the difficulty of obtaining tissue samples and of isolating a pure population of huSCs (Boldrin et al., 2010). By comparison, techniques for the prospective isolation of mouse SCs have identified a well-defined myogenic SC popula

• In summary we demonstrated that OCT is critical for mesendod

  2018-11-08

  

  In summary, we demonstrated that OCT4 is critical for mesendoderm differentiation by showing its involvement in eviction of the PRC2 complex and loss of the H3K27me3 mark from mesendodermal genes. The effect on SOX17 is most revealing as it demonstrates pre-patterning of this gene prior to gene expr

• br Experimental Procedures br Author Contributions br Acknow

  2018-11-08

  

  Experimental Procedures Author Contributions Acknowledgments The authors thank Chyuan-Sheng Lin from the Transgenic Mouse Facility at the Herbert Irving Comprehensive Cancer Center at Columbia University for development of the Zfyve27-CreERT2 mice; Theresa Swayne from the Confocal and Speci

• Further studies were carried out on

  2018-11-08

  

  Further studies were carried out on miR-146a-5p, which is thought to be a mediator of inflammation, and a regulator of IL-6 and IL-8 and the expression of the immune receptors TLR2 and 4 (Taganov et al., 2006). TLRs are present on a range of non-immune cells, and a number (predominantly TLR2 and TLR

• The phenotype and fate of a given cell

  2018-11-08

  

  The phenotype and fate of a given cell relies on the precise control of gene expression by complex transcriptional and epigenetic networks. Such regulation of gene expression is essential for proper differentiation, cellular function, development, and homeostasis (Feng et al., 2010; Reik, 2007). His

• Noticeably the redistribution of protein from

  2018-11-07

  

  Noticeably, the redistribution of protein from the cytoplasm to the nucleus was observed in many regulatory molecules, such as nuclear factor κB (Haddad, 2009) and AKT (Xuan et al., 2006). We thus speculated that the increased nuclear MIF in hypoxic tumors may interact with the transcription factors

• Social capital and social support have

  2018-11-07

  

  Social capital and social support have often been distinguished according to the ecological level in which these social influences are viewed to operate. Social capital has conventionally been seen as a property of groups or places, with social support more often conceptualized as an individual-leve

• br Background In such nonparametric variables

  2018-11-07

  

  Background In 1990, such nonparametric variables were primarily proposed by Witting et al., who had studied the effect of age and Alzheimer׳s disease on rest–activity rhythm [12]. These variables quantify the main characteristics of the rest–activity circadian rhythm, such as intradaily variabili

• br En el verano del a o el

  2018-11-07

  

  En el verano del año 2010 el Consejo General del Banco Central Europeo decidió que el conjunto de 27 bancos centrales de la Unión Europea participaran conjuntamente en una investigación formulando nuevos conceptos, modelos y medidas de regulación y supervisión macroprudencial. El grupo de investig

• Binary panel models can be estimated by the random effects

  2018-11-07

  

  Binary panel models can be estimated by the random effects methods (RE), in which the specific effect of the individual α is treated as a random variable with distribution g (α/γ), in which γ denotes additional parameters. Frequently, this is a normal distribution. Thus, the α is eliminated by integ

• Linnman et al reanalyzed the NK

  2018-11-07

  

  Linnman et al. (2012) reanalyzed the NK1 receptor data in cWAD patients and healthy controls from an already published study (Linnman et al., 2010). This was done to validate if the NK1 receptor availability was altered in the posterior parietal occipital region as previously reported by others (Lin

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