• The situation in primates is complex Several

  2018-10-24

  

  The situation in primates is complex. Several studies have reported the reversion of conventional human ESCs to naive-like pluripotency (Fig. 1D), using different combinations of transcription factors (KLF2, NANOG, and STAT3), growth factors (LIF, Activin, and FGF2), and chemical inhibitors of vario

• The Sonic Hedgehog SHH pathway is active

  2018-10-24

  

  The Sonic Hedgehog (SHH) pathway is active in the adult SEZ, where it has been proposed to regulate cell proliferation (Ruat et al., 2012; Ahn and Joyner, 2005; Machold et al., 2003) and to modulate the migration of neuroblasts exiting the niche (Angot et al., 2008). The mosaic inactivation of the S

• phosphatase inhibitor br Experimental Procedures br Acknowle

  2018-10-24

  

  Experimental Procedures Acknowledgments Introduction Spermatogonial stem phosphatase inhibitor (SSCs) give rise to the spermatogenesis that endures throughout the life of male animals (de Rooij and Russell, 2000; Meistrich and van Beek, 1993). SSCs reside in a special microenvironment term

• Retinoblastoma proteins complex with E F and DP family trans

  2018-10-24

  

  Retinoblastoma proteins complex with E2F and DP family transcriptional repressor proteins (Bertoli et al., 2013) to both activate and repress gene expression associated with regulation of cell-cycle repression and differentiation. Rbf-E2F1-DP complexes regulate transient gene expression necessary fo

• bcrp inhibitor The liver is composed of

  2018-10-24

  

  The liver is composed of multiple cellular lineages, including hepatocytes, cholangiocytes (biliary epithelial cells), hepatic stellate cells, Kupffer bcrp inhibitor (hepatic macrophages), myofibroblasts, vascular and sinusoidal endothelial cells, and circulating hematopoietic cells. HPCs are define

• We previously reported that D retinal tissue differentiated

  2018-10-24

  

  We previously reported that 3D retinal tissue differentiated from mESC or mouse iPSC (miPSC) retina can develop a structured ONL of fully mature photoreceptors with outer-segment structures when transplanted into rd1 end-stage retinal-degeneration model mice, possibly by forming synapses with host b

• br Experimental Procedures br Author Contributions br Acknow

  2018-10-24

  

  Experimental Procedures Author Contributions Acknowledgments We thank A. Villanueva, C. Saura, C. Cruz, A. Fernández, E. Nadal, M. Martin, and R. Iggo for reagents and helpful advice, A. Welm and Y. DeRose for sharing PDX models, V. Peg, X. Serres, J. Balmaña, J. Pérez, and C. Hierro for pr

• The reconstruction of mesons was done using their

  2018-10-24

  

  The reconstruction of φ-mesons was done using their decay channel into two charged kaons, φ→К+К−. Charged particle tracks were reconstructed in two main tracking detectors of the ALICE experiment: TPC (Time Projection Chamber) and ITS (Inner Tracking System). Because of the high multiplicity of part

• where the value of the parameter is determined by the

  2018-10-24

  

  where the value of the parameter is determined by the focusing angle , and () is the arbitrary dependence satisfying the condition () ≠ 0. Let us list as an example the potentials implementing the above-described arrival function at =0, 1, 2 and at ()=1: where was determined earlier in formula

• The present work reports for the first time the synthesis

  2018-10-24

  

  The present work reports for the first time the synthesis of Ca5(PO4)3Cl:Eu2+ phosphor via the Pechini (citrate gel) method and the investigation of its photoluminescent properties. Experimental For synthesis of Eu2+ activated chlorapatite phosphor Ca5(PO4)3Cl stoichiometric amount of the precur

• At the IV III phase

  2018-10-24

  

  At the IV→III phase transition, the third harmonic coefficient γ3ω for nanostructured (as well as for bulk) potassium iodate (Fig. 3b) takes the minimal value, increasing by about four times with further heating. Thus, the temperature studies of the capacitance and the third harmonic coefficient hav

• Low household income and educational attainment

  2018-10-24

  

  Low household income and educational attainment are associated with material deprivation and reduced opportunities for children that order Embelin in turn predict the onset and severity of childhood mental health problems (Evans, 2004; McLaughlin et al., 2011; Reiss, 2013). However beyond material

• Most existing work including studies

  2018-10-24

  

  Most existing work, including studies by Sayed and Zhang, used some variation of degree centrality to evaluate network-based interventions. As Valente (2010) points out, a major limitation of in-degree centrality is that nominations received may be redundant. Borgatti (2006) showed that conventional

• However Foucault claims that political

  2018-10-23

  

  However, Foucault claims that political economy in fact was the first economic school of thought to represent the beginning of a new governmentality by dividing power, knowledge, government and science properly. Foucault (2004, pp. 350–351) says that, unlike the resorts used by 17th century raison d

• br Methods br Results br

  2018-10-23

  

  Methods Results Discussion However, this novel treatment only applies to 9 of the 1900 CFTR gene mutations reported to date (~5% of all CF patients). The CF community should thus work fast to determine whether ivacaftor, or the investigational drug lumacaftor (for Class II mutants) rescue o

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