• br Conflict of interest br Acknowledgement br

  2018-10-22

  

  Conflict of interest Acknowledgement Introduction Diabetes mellitus (DM) is a serious global health program which is characterized by high blood glucose levels, which lead to complications such as retinopathy, hypertension, neuropathy and diabetic foot ulcers [1]. Type 2 DM caused by defect

• A repeatable and scalable process of hES cell derivation

  2018-10-22

  

  A repeatable and scalable process of hES cell derivation and scale-up would require a xenofree, clinical grade feeder cell line. Choo et al. generated a hES feeder cell line using HPV E6/E7 immortalization but this line has not become widely used (Choo et al., 2006). More recently Unger et al. used

• The goals of the current study were to investigate

  2018-10-22

  

  The goals of the current study were to investigate the changes in anal sphincter pressure after IV or IM injection of MSCs in our previously established animal models. Our models (Salcedo et al., 2010; Zutshi et al., 2009a) allow measurement of anal sphincter pressure and EMG in vivo in a repeated,

• galanin Because many growth factors function in a context de

  2018-10-22

  

  Because many growth factors function in a context-dependent manner, we explored the effects of adding WNT3A to the MC on the growth of Bl-CFCs. In cultures containing a combination of hematopoietic growth factors (VEGF, SCF, IL-3, IL-6, thrombopoietin [TPO], EPO, and FLT3L), 0.2%–0.6% of galanin de

• Our observation of different rates

  2018-10-22

  

  Our observation of different rates of proliferation in the basal cell layer of tail IFE is consistent with earlier findings (Mascré et al., 2012). However, this difference is not due to slow-cycling stem Y-27632 giving rise to rapidly cycling committed progenitors (Mascré et al., 2012). Instead, sc

• To meet this current need our

  2018-10-22

  

  To meet this current need, our goal was to develop a tool that would make automated cell segmentation feasible and efficient in analyzing data from higher organisms, as has been applied to less complex data from lower organisms, such as in bacteria (Locke and Elowitz, 2009). The objective was to ass

• Inner pillar cells express Fgfr which may contribute to thei

  2018-10-22

  

  Inner pillar cells express Fgfr3, which may contribute to their capacity for regeneration (Jacques et al., 2007). Supporting cells in the chicken basilar papilla express Fgfr3, which is transiently downregulated during hair cell regeneration (Bermingham-McDonogh et al., 2001). Fgfr3−/− mice lack in

• A potent methodology was recently developed to generate a

  2018-10-22

  

  A potent methodology was recently developed to generate a highly enriched population of floor-plate-derived midbrain lineage ESC-mDA and iPSC-mDA neurons sufficient to treat the large PD patient population (Kriks et al., 2011). Cellular Dynamics International made a critical translational advancemen

• br Materials and methods br Results br Discussion

  2018-10-22

  

  Materials and methods Results Discussion Posttranscriptional regulation mechanisms are now considered to play a key role in the control of gene expression. Regulation occurs mainly through the modulation of mRNA half life or the formation of a translational initiation complex, allowing the

• Although the expression of bisect type N glycans during

  2018-10-20

  

  Although the chk1 inhibitor of bisect-type N-glycans during neuronal differentiation was significantly up-regulated, this did not occur during glial differentiation. This result indicates that increased bisect-type N-glycan expression is specific to neuronal differentiation. Therefore, bisecting ty

• Several studies have reported pivotal

  2018-10-20

  

  Several studies have reported pivotal roles for some miRNAs in hBMSC-lineage commitment and fate determination that are mediated by their ability to modulate differentiation-regulating factors. For instance, miR-210, miR-206, miR-133, miR-2861, and miR-138 have been implicated in the regulation of o

• To investigate whether PD derived HSCs

  2018-10-20

  

  To investigate whether PD-derived HSCs exist in other mammals, we analyzed the resident cells in the peritoneal cavity of C57BL/6 mice without any prior treatment. We found that there was a higher ratio (0.51±0.04%) of Lin−/Sca1+/c-kit+ population in the mouse peritoneal cavity than in bone marrow (

• br Materials and methods br

  2018-10-20

  

  Materials and methods Acknowledgments We would like to thank Ida Jørring and Anita Pacht for their excellent technical assistance. This project was funded by the European Union 7th Framework Program (PIAPP-GA-2012-324451-STEMMAD) and Innovation Fund Denmark through BrainStem. Resource table

• br Resource table br Resource details Spastic paraplegia

  2018-10-20

  

  Resource table Resource details Spastic paraplegia gene type 5 (SPG5) is an autosomal recessive subtype of hereditary spastic paraplegia caused by mutations in CYP7B1, a gene encoding for the cytochrome P-450 oxysterol 7-α-hydroxylase, essential for the liver-specific alternative pathway in bi

• More recently work has been performed in

  2018-10-20

  

  More recently, work has been performed in the NHP species, Macaca fasicularis (the crab-eating macaque), in which autologously transplanted iPS-derived dopamine neurons were able to survive and restore motor deficits for up to 2years (Hallett et al., 2015). However, the degree to which studies inves

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