• To investigate whether PD derived HSCs

  2018-10-20

  

  To investigate whether PD-derived HSCs exist in other mammals, we analyzed the resident cells in the peritoneal cavity of C57BL/6 mice without any prior treatment. We found that there was a higher ratio (0.51±0.04%) of Lin−/Sca1+/c-kit+ population in the mouse peritoneal cavity than in bone marrow (

• br Materials and methods br

  2018-10-20

  

  Materials and methods Acknowledgments We would like to thank Ida Jørring and Anita Pacht for their excellent technical assistance. This project was funded by the European Union 7th Framework Program (PIAPP-GA-2012-324451-STEMMAD) and Innovation Fund Denmark through BrainStem. Resource table

• br Resource table br Resource details Spastic paraplegia

  2018-10-20

  

  Resource table Resource details Spastic paraplegia gene type 5 (SPG5) is an autosomal recessive subtype of hereditary spastic paraplegia caused by mutations in CYP7B1, a gene encoding for the cytochrome P-450 oxysterol 7-α-hydroxylase, essential for the liver-specific alternative pathway in bi

• More recently work has been performed in

  2018-10-20

  

  More recently, work has been performed in the NHP species, Macaca fasicularis (the crab-eating macaque), in which autologously transplanted iPS-derived dopamine neurons were able to survive and restore motor deficits for up to 2years (Hallett et al., 2015). However, the degree to which studies inves

• The pluripotency of MPSII line was confirmed by alkaline

  2018-10-20

  

  The pluripotency of MPSII-4.1 line was confirmed by alkaline phosphatase staining (ALP) and by immunocytochemistry staining (ICC) for endogenous NANOG and -CADHERIN (B) after silencing of the exogenous hOKSM construct. The spontaneous differentiation potential of the iPSC line towards the three ge

• Telomere elongation is one of

  2018-10-20

  

  Telomere elongation is one of the hallmarks of the reprogramming process, and we previously showed that this is a two-step process: it starts during reprogramming and then continues while iPSCs have obtained full pluripotent status (Marion et al., 2009). In Sirt1−/− cells, the telomere elongation af

• The meniscus is best described as

  2018-10-20

  

  The meniscus is best described as a fibrocartilage (Benjamin and Evans, 1990) comprising an outer, “red vascularized” part and an inner “white, unvascularized” part harboring round fibrochondrocytes (Hellio Le Graverand et al., 2001). Additionally, the outer surface of the meniscus is enclosed by a

• Our findings showing an increase of growth factors expressio

  2018-10-20

  

  Our findings showing an increase of growth factors expression in miR133-CPCs upon stress conditioning and the amelioration of cardiac functions after miR133-CPCs transplantation post-AMI are in agreement with a recent publication that demonstrates that previous supplementation (“priming”) of SCA1+/C

• We exploited C MYC to activate the endogenous c

  2018-10-20

  

  We exploited C-MYC to activate the endogenous c-Myc gene and enhance gene expression in neurosensory cell types. By doing so, we derived a self-renewing immortalized multipotent otic progenitor (iMOP) line from SOX2-expressing neurosensory precursors of the inner ear. We show that the endogenous C-M

• T-5224 Owing to the colocalization between mitochondria and

  2018-10-20

  

  Owing to the colocalization between mitochondria and the germ plasm of some animals, models whereby the Balbiani body selects the healthiest mitochondria for the next generation have been proposed (Cox and Spradling, 2003; Pepling and Spradling, 1998). Early as well as more recent studies thus exami

• c Kit RP http www epitopeptide com image s S

  2018-10-20

  

  c-Kit+ RPCs are distributed from the central to the peripheral regions of the retina, but not in the ciliary bodies, which were previously proposed to house retinal progenitors (Cicero et al., 2009; Martinez-Navarrete et al., 2008). These data suggest that c-Kit+ RPCs are a distinct population of to

• Understanding http www apexbt com media

  2018-10-20

  

  Understanding the regulatory pathways that control the establishment of the different hematopoietic programs and developing methods to identify and isolate progenitors for each are essential to accurately model hematopoiesis in ESC and induced PSC differentiation cultures and ultimately to generate

• In the dermis the glial P NGFR positive BC derivatives

  2018-10-20

  

  In the dermis, the glial P75NGFR-positive BC derivatives also include a neurogenic and gliogenic stem-like cell population. Multipotent stem-like cell populations have been described previously in the adult trunk skin, associated with the glial and melanocyte lineages and derived from the NC (Wong e

• Given that a global effort has

  2018-10-20

  

  Given that a global effort has been initiated to develop donor banks of human leukocyte antigen (HLA)-matched iPSC banks that will serve as an extensive library for selecting close to optimal matches for patients (Turner et al., 2013; Fairchild 2015; Solomon et al., 2015), it is clear that the need

• br Results br Discussion This study

  2018-10-20

  

  Results Discussion This study describes a simplified protocol for the efficient generation of hiNSCs via direct reprogramming. hiNSC lines grow as colonies on MEF feeder layers. Like hESCs, hiNSCs stain positive for pluripotent transcription factors OCT4, SOX2, and NANOG, but do not express ce

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